(RS)-(±)-Sulpiride

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(RS)-(±)-Sulpiride | CAS No. 15676-16-1 | Non-selective Dopamine Receptor Antagonists
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Description: Standard selective D2-like antagonist

Chemical Name: (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide

Purity: ≥99%

Product Details
Citations (7)
Supplemental Products
Reviews (2)

Biological Activity

(RS)-(±)-Sulpiride is a standard D2-like dopamine receptor antagonist.

S-enantiomer also available.

Technical Data

M.Wt:
341.42
Formula:
C15H23N3O4S
Solubility:
Soluble to 50 mM in 1eq. HCl with gentle warming and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
15676-16-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  2. DA D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
    Seeman and Van Tol
    Eur.J.Pharmacol., 1993;233:173

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Citations for (RS)-(±)-Sulpiride

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Inhibition of Synaptic Transmission in the VP
By Anonymous on 02/02/2020
Application: Species: Mouse

sulpiride (1 μM)

PMID: 29949769

Sulpiride reverses quinpirole effects on dopamine release
By Anonymous on 03/28/2018
Application: Species: Mouse

In voltammetry experiments measuring evoked dopamine release, quinpirole was used to activate D2 receptors to inhibit dopamine release. Sulpiride (600 nM) was applied afterward to reverse quinpirole effects.


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