Catalog Number: 2970
Chemical Name: (7α,17α)-17-Hydroxy-3-oxo-7-propylpregn-4-ene-21-carboxylic acid γ-lactone
Biological Activity
Mineralocorticoid receptor antagonist. Prevents aldosterone-induced hypertension in rats.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of antimineralocorticoid RU 26752 on steroid-induced hypertension in rats.
    Kalimi et al.
    Am.J.Physiol., 1990;258:E737
  2. Structural basis of spirolactone recognition by the mineralocorticoid receptor.
    Huyet et al.
    Mol.Pharmacol., 2007;72:563
  3. Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists.
    Lazar and Agarwal
    Biochem.Biophy.Res.Comms., 1986;134:261

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    2970 has been discontinued.

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