Catalog Number: 0307
Biological Activity
Demonstrates high affinity for the kainate receptor subtype hGluR5 (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluR6.
Technical Data
  • M.Wt:
    325.06
  • Formula:
    C7H8IN3O4
  • Solubility:
    Soluble to 25 mM in 1.1eq. NaOH
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    140187-25-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
    Jane et al.
    J.Med.Chem., 1997;40:3645
  2. Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
    Patneau et al.
    J.Neurosci., 1992;12:595
  3. Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones.
    Wong et al.
    J.Neurosci., 1994;14:3881
  4. Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.
    Swanson et al.
    Mol.Pharmacol., 1998;53:942
  5. Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots.
    Thompson et al.
    Br.J.Pharmacol., 1996;117:331P
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:

1 Citations: Showing 1 - 1

  1. Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
    Authors: Pansiot Et al.
    Proc Natl Acad Sci U S A 2010;5:e10916

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