Biological ActivityDemonstrates high affinity for the kainate receptor subtype hGluK1 (formally hGluR5) (Ki = 0.24 nM) and 600-4000-fold selectivity over both the AMPA receptor subtypes and the homomeric kainate receptor hGluK2 (formally hGluR6).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
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Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.
Jane et al.
Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.
Patneau et al.
Kainate receptors exhibit differential sensitivities to (S)-5-iodowillardiine.
Swanson et al.
Willardiines differentiate agonist binding sites for kainate-versus AMPA-preferring glutamate receptors in DRG and hippocampal neurones.
Wong et al.
Depolarising effects of certain derivatives of (S) willardiine upon in vitro neonatal rat dorsal roots.
Thompson et al.
Citation for (S)-(-)-5-Iodowillardiine
The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-5-Iodowillardiine include:
1 Citation: Showing 1 - 1
Neuroprotective effect of inhaled nitric oxide on excitotoxic-induced brain damage in neonatal rat.
Authors: Pansiot Et al.
Proc Natl Acad Sci U S A 2010;5:e10916
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