Catalog Number: 1546
Chemical Name: (4S)-1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester
Biological Activity
L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo.

Racemate and (R)-(+)-Enantiomer also available.

Technical Data
  • M.Wt:
    356.3
  • Formula:
    C16H15F3N2O4
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    98625-26-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. The optical isomers of the 1,4-dihydropyridine BAY K 8644 show opposite effects on Ca channels.
    Franckowiak et al.
    Eur.J.Pharmacol., 1985;114:223
  2. Opposite cardiac actions of the enantiomers of Bay K 8644 at different membrane potentials in guinea-pig papillary muscles.
    Ravens and Schopper
    Naunyn Schmiedebergs Arch.Pharmacol., 1990;341:232
  3. Enantiomer selectivity and the development of tolerance to the behavioral effects of the calcium channel activator BAY K 8644.
    O'Neill and Bolger
    Brain Res.Bull., 1988;21:865
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Bay K 8644 include:

2 Citations: Showing 1 - 2
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  1. Spectrum of Cav1.4 dysfunction in congenital stationary night blindness type 2.
    Authors: Burtscher Et al.
    Biochim Biophys Acta 2014;1838:2053
  2. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
    Authors: Landstrom Et al.
    Eneuro 2011;4:214

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