Catalog Number: 1852
Chemical Name: (3aS)-(-)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Biological Activity
Selective inhibitor of myosin II ATPase activity (IC50 ~0.5 - 5 μM); active enantiomer of (±)-blebbistatin (Cat. No. 1760). Inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly. Rapidly and reversibly blocks cell blebbing, and disrupts directed cell migration and cytokinesis in vertebrate cells.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Specificity of blebbistatin, an inhibitor of myosin II.
    Limouze et al.
    J.Muscle Res.Cell Motil., 2004;25:337
  2. Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor.
    Straight et al.
    Science, 2003;299:1743
  3. Dissecting cytokinesis with small molecules.
    Straight et al.
    Amer.Soc.Cell Biol.Abstr., 2002;:2515
Tocris Small Molecules
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