(S)-(+)-Dimethindene maleate

  ( 2 citations )    
Product Datasheet
Catalog Number:1425
Chemical Name:N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
Product Details
Citations (2)
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Biological Activity
Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.
Technical Data
  • M.Wt:
    408.5
  • Formula:
    C20H24N2.C4H4O4
  • Solubility:
    Soluble to 100 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    136152-65-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:

2 Citations: Showing 1 - 2
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  1. Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency.
    Authors: Yang Et al.
    Cell.  2017;169:243
  2. Differential roles of M2 and M3 muscarinic receptor subtypes in modulation of bladder afferent activity in rats.
    Authors: Matsumoto Et al.
    Urology  2010;75:862

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