(S)-(+)-Dimethindene maleate

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(S)-(+)-Dimethindene maleate | CAS No. 136152-65-3 | mAChR M2 Antagonists
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Description: Selective M2 antagonist

Chemical Name: N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate

Purity: ≥99%

Product Details
Citations (6)
Supplemental Products
Reviews (1)

Biological Activity

Enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

Technical Data

M.Wt:
408.5
Formula:
C20H24N2.C4H4O4
Solubility:
Soluble to 100 mM in water with gentle warming
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
136152-65-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (S)-(+)-Dimethindene maleate

The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Dimethindene maleate include:

6 Citations: Showing 1 - 6

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Generation of EPS-blastoids
By Anonymous on 02/27/2020
Application: Species: Mouse

2uM

PMID: 31626770

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