Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer
(Cat. No. 0281) also available.
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All Tocris products are intended for laboratory research use only.
Other Product-Specific Information:
Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative.
Singh et al.
Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro.
Grobaski et al.
(±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism.
Shepard and Lehmann