Catalog Number: 0282
Chemical Name: (S)-(-)-3-Amino-1-hydroxypyrrolidin-2-one
Biological Activity
Possesses potent sedative and ataxic action, probably through disruption of striatal dopaminergic mechanisms. R-enantiomer (Cat. No. 0281) also available.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolidin-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA966 is a potent γ-butyrolactone-like sedative.
    Singh et al.
    Proc.Natl.Acad.Sci.U.S.A., 1990;87:347
  2. Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro.
    Grobaski et al.
    Br.J.Pharmacol., 1997;120:575
  3. (±)-1-Hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor mediated mechanism.
    Shepard and Lehmann
    J.Pharmacol.Exp.Ther., 1992;261:387
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