Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Biological Activity5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol.
Racemate also available.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain.
Corradetti et al.
β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists.
Stimulant and blocking effects of optical isomers of pin. on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation.
Walter et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1984;327:159
Citation for (S)-(-)-Pindolol
The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:
1 Citation: Showing 1 - 1
Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation.
Authors: Kaya Et al.
Front Neurosci 2009;329:350
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