Chemical Name: (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Biological ActivityLess active enantiomer of the PDE4 inhibitor Rolipram.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
Ohsawa et al.
Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
Owens et al.
Stereospecific binding of the antidepressant rolipram to brain protein structures.
Schneider et al.
Citations for (S)-(+)-Rolipram
The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Rolipram include:
4 Citations: Showing 1 - 4
Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.
Authors: Brancaleone Et al.
J Pharmacol Exp Ther 2014;351:96
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
Authors: Boomkamp Et al.
J Biol Chem 2014;171:2385
Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization.
Authors: Meyer Et al.
Int J Nanomedicine 2012;7:2449
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Authors: Lee Et al.
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