(S)-(+)-Rolipram (CAS 85416-73-5): R&D Systems
Catalog Number: 1350
Chemical Name: (4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
Biological Activity

Less active enantiomer of the PDE4 inhibitor Rolipram.

Racemate and R-enantiomer also available.
Technical Data
  • M.Wt:
    275.35
  • Formula:
    C16H21NO3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    85416-73-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains.
    Ohsawa et al.
    Jpn.J.Pharmacol., 1998;77:147
  2. Human phosphodiesterase 4A: characterization of full-length and truncated enzymes expressed in COS cells.
    Owens et al.
    Biochem.J., 1997;326:53
  3. Stereospecific binding of the antidepressant rolipram to brain protein structures.
    Schneider et al.
    Eur.J.Pharmacol., 1986;127:105
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-(+)-Rolipram include:

4 Citations: Showing 1 - 4
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  1. Annexin A1 mediates hydrogen sulfide properties in the control of inflammation.
    Authors: Brancaleone Et al.
    J Pharmacol Exp Ther 2014;351:96
  2. Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model.
    Authors: Boomkamp Et al.
    J Biol Chem 2014;171:2385
  3. Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization.
    Authors: Meyer Et al.
    Int J Nanomedicine 2012;7:2449
  4. The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
    Authors: Lee Et al.
    Nature 2012;492:123
Tocris Small Molecules
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Rolipram

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