Catalog Number: 0895
Chemical Name: (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide
Biological Activity
Active enantiomer. Selective D2-like dopamine antagonist (Ki values are ~ 0.015. ~ 0.013, 1, ~ 45 and ~ 77 μM at D2, D3, D4, D1 and D5 receptors respectively).

Racemate also available.

Technical Data
  • M.Wt:
    341.42
  • Formula:
    C15H23N3O4S
  • Solubility:
    Soluble to 10 mM in ethanol with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    23672-07-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. Dopamine D4 receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective.
    Seeman and Van Tol
    Eur.J.Pharmacol., 1993;233:173
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-(-)-Sulpiride include:

13 Citations: Showing 1 - 10
Filter your results:

  1. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife 2015;4
  2. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim Et al.
    J Neurophysiol 2015;35:6307
  3. Agonist and antagonist effects of aripiprazole on D2-like receptors controlling rat brain dopamine synthesis depend on the dopaminergic tone.
    Authors: Ma Et al.
    Int J Neuropsychopharmacol 2015;18
  4. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    J Clin Invest 2015;112:8124
  5. Effects of Dopamine D2-Like Receptor Antagonists on Light Responses of Ganglion Cells in Wild-Type and P23H Rat Retinas.
    Authors: Jensen
    PLoS One 2015;10:e0146154
  6. Phasic dopamine release drives rapid activation of striatal D2-receptors.
    Authors: Marcott Et al.
    Neuron 2014;84:164
  7. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.
    Authors: Dragicevic Et al.
    J Neurosci 2014;137:2287
  8. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole.
    Authors: Ishima Et al.
    Transl Psychiatry 2012;2:e170
  9. HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
    Authors: Kurita Et al.
    Nat Neurosci 2012;15:1245
  10. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience 2009;164:1068
  11. Co-transmission of dopamine and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    Proc Natl Acad Sci U S A 2008;99:1559
  12. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci 2008;28:8040
  13. Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
    Authors: Wang Et al.
    Neuron 2006;50:443
Expand to show all 13 Citations

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