Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt
Biological ActivityInhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
Ferry et al.
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.
Li et al.
Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells.
Gaetano et al.
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