Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt
Biological ActivityS 32826 is an inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
Ferry et al.
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.
Li et al.
Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells.
Gaetano et al.
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