Inhibitor of autotaxin (IC50
= 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α
). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μ
M. Inhibits LPA release from adipocytes (IC50
= 90 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
Ferry et al.
Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.
Li et al.
Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells.
Gaetano et al.