S 32826

Catalog # Availability Size / Price Qty
3404/10
S 32826 | CAS No. 1103672-43-0 | Autotaxin Inhibitors
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Description: Potent autotaxin inhibitor

Chemical Name: [4-(Tetradecanoylamino)benzyl]phosphonic acid disodium salt

Purity: ≥98%

Product Details
Reviews

Biological Activity

Inhibitor of autotaxin (IC50 = 9 nM). Displays similar inhibitory effects at all three autotaxin isoforms (α, β and γ). Exhibits no affinity for lysophosphatidic acid receptor 1 (LPA1) at concentrations up to 10 μM. Inhibits LPA release from adipocytes (IC50 = 90 nM).

Technical Data

M.Wt:
441.45
Formula:
C21H34NO4PNa2
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1103672-43-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. S32826, a nanomolar inhibitor of autotaxin: discovery, synthesis and applications as a pharmacological tool.
    Ferry et al.
    J.Pharmacol.Exp.Ther., 2008;327:809
  2. Autotaxin is induced by TSA through HDAC3 and HDAC7 inhibition and antagonizes the TSA-induced cell apoptosis.
    Li et al.
    Mol.Cancer, 2011;10:18
  3. Inhibition of autotaxin production or activity blocks lysophosphatiylcholine-induced migration of human breast cancer and melanoma cells.
    Gaetano et al.
    Mol.Carcinogenesis, 2009;48:801

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