Biological ActivityEndothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
(Modifications: Disulfide bridge between 1 - 15, 3 - 11)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Endothelin-induced nociception in mice: mediation by ETA and ETB receptors.
Raffa et al.
Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds.
Minkes et al.
Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery.
Schoeffter and Randriantsoa
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