Catalog Number: 1899
Biological Activity
Endothelin receptor agonist (EC50 values are 7.5 and > 150 nM for contraction of pig coronary artery and guinea pig aorta respectively). Nociceptive in vivo.
Technical Data
  • M.Wt:
    2514.85
  • Formula:
    C105H156N28O34S5
  • Sequence:
    CSCKDMTDKECLNFCHQDVIW

    (Modifications: Disulfide bridge between 1 - 15, 3 - 11)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    126738-34-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Comparison of responses to sarafotoxins 6a and 6c in pulmonary and systemic vascular beds.
    Minkes et al.
    Am.J.Physiol., 1992;262:H852
  2. Differences between endothelial receptors mediating contraction of guinea-pig aorta and pig coronary artery.
    Schoeffter and Randriantsoa
    Eur.J.Pharmacol., 1993;249:199
  3. Endothelin-induced nociception in mice: mediation by ETA and ETB receptors.
    Raffa et al.
    J.Pharmacol.Exp.Ther., 1996;276:647

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