SIB 1508Y maleate
Chemical Name: 3-Ethynyl-5-[(2S)-1-methyl-2-pyrrolidinyl]pyridine maleate salt
Biological ActivityPotent neuronal nicotinic ACh receptor agonist (EC50 values are 1.8, 5, 9 and 23 nM for α4β2, α2β4, α4β4 and α3β4 receptors respectively). Improves cognitive function in a MPTP-induced model of Parkinson's Disease in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Cosford et al.
Nicotinic acetylcholine receptor agonist SIB-1508Y improves cognitive functioning in chronic low-dose MPTP-treated monkeys.
Schneider et al.
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