Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide
Biological ActivityEndogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
Chu et al.
Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels.
De Petrocellis et al.
Citation for STEARDA
The citations listed below are publications that use Tocris products. Selected citations for STEARDA include:
1 Citation: Showing 1 - 1
Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation.
Cell Rep 2017;19(10):2074
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