Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1
receptors (at concentrations up to 5 μ
M) and does not inhibit AMT or FAAH (IC50
> 25 μ
M). However, potentiates TRPV1-mediated effects of NADA in vitro
and in vivo
; enhances effects on intracellular Ca2+
lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50
= 16 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
Chu et al.
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
De Petrocellis et al.