Catalog Number: 2204
Alternate Names: N-Stearoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide
Biological Activity
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
Technical Data
  • M.Wt:
    419.64
  • Formula:
    C26H45NO3
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    105955-10-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
    Chu et al.
    J.Biol.Chem., 2003;278:13633
  2. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
    De Petrocellis et al.
    Br.J.Pharmacol., 2004;143:251
Citations:

The citations listed below are publications that use Tocris products. Selected citations for STEARDA include:

1 Citations: Showing 1 - 1

  1. Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation.
    Authors: Arensdorf
    Cell Rep 2017;19(10):2074

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