Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide
Biological ActivityEndogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
Chu et al.
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
De Petrocellis et al.
Citation for STEARDA
The citations listed below are publications that use Tocris products. Selected citations for STEARDA include:
1 Citation: Showing 1 - 1
Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation.
Cell Rep 2017;19(10):2074
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