Inhibitor of Ca2+
channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50
= 1.8 μ
M in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro
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TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
Namkung et al.
Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells.
Mroz and Keely
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.
Duvvuri et al.
Cancer Res. [Epub ahead of print], 2012;
The citations listed below are publications that use Tocris products. Selected citations for T16Ainh - A01 include:
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