T16Ainh - A01

Catalog # Availability Size / Price Qty
4538/10
4538/50
T16Ainh - A01 | CAS No. 552309-42-9 | Calcium-activated Chloride Channel Blockers
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Description: Ca2+-activated Cl- channel transmembrane protein 16A (TMEM16A) inhibitor

Chemical Name: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide

Purity: ≥98%

Product Details
Citations (8)
Reviews

Biological Activity

Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.

Technical Data

M.Wt:
416.52
Formula:
C19H20N4O3S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
552309-42-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for T16Ainh - A01

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