T16Ainh - A01

  ( 7 citations )    
Product Datasheet
Catalog Number:4538
Chemical Name:2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
Product Details
Citations (7)
Reviews
Biological Activity
Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
Technical Data
  • M.Wt:
    416.52
  • Formula:
    C19H20N4O3S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Store at +4°C
  • CAS No:
    552309-42-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for T16Ainh - A01 include:

7 Citations: Showing 1 - 7
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  1. TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients.
    Authors: Zhang Et al.
    Mol Pain  2015;7:367
  2. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
    Authors: Pineda-Farias Et al.
    Cell Death Dis  2015;11:41
  3. Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
    Authors: Zhang Et al.
    PLoS One  2015;10:e0142160
  4. Anoctamin-1 in the juvenile rat urinary bladder.
    Authors: Bijos Et al.
    PLoS One  2014;9:e106190
  5. Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.
    Authors: Bill Et al.
    J Biol Chem  2014;289:11029
  6. Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.
    Authors: Jeon Et al.
    PLoS One  2013;8:e67989
  7. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    PLoS One  2013;4:e969

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