T16Ainh - A01
Chemical Name: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
Biological ActivityInhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
Namkung et al.
Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells.
Mroz and Keely
TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.
Duvvuri et al.
Cancer Res. [Epub ahead of print], 2012;
Citations for T16Ainh - A01
The citations listed below are publications that use Tocris products. Selected citations for T16Ainh - A01 include:
8 Citations: Showing 1 - 8
Long-term DEX treatment diminishes store-operated Ca2+ entry in salivary acinar cells.
Authors: Kusuda Et al.
Int J Oral Sci 2019;11:1
TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients.
Authors: Zhang Et al.
Mol Pain 2015;7:367
Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
Authors: Pineda-Farias Et al.
Cell Death Dis 2015;11:41
Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
Authors: Zhang Et al.
PLoS One 2015;10:e0142160
Anoctamin-1 in the juvenile rat urinary bladder.
Authors: Bijos Et al.
PLoS One 2014;9:e106190
Small molecule-facilitated degradation of ANO1 protein: a new targeting approach for anticancer therapeutics.
Authors: Bill Et al.
J Biol Chem 2014;289:11029
Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.
Authors: Jeon Et al.
PLoS One 2013;8:e67989
Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
Authors: Harper and Poole
PLoS One 2013;4:e969
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