Catalog Number: 4538
Chemical Name: 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide
Biological Activity
Inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Inhibits EGF-induced increases in CaCC currents; blocks proliferation of tumor cells in vitro.
Technical Data
  • M.Wt:
    416.52
  • Formula:
    C19H20N4O3S2
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    552309-42-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells.
    Namkung et al.
    J.Biol.Chem., 2011;286:2365
  2. Epidermal growth factor chronically upregulates Ca2+-dependent Cl- conductance and TMEM16A expression in intestinal epithelial cells.
    Mroz and Keely
    J.Physiol., 2012;590:1907
  3. TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression.
    Duvvuri et al.
    Cancer Res. [Epub ahead of print], 2012;
Citations:

The citations listed below are publications that use Tocris products. Selected citations for T16Ainh - A01 include:

5 Citations: Showing 1 - 5
Filter your results:

  1. TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients.
    Authors: Zhang Et al.
    Mol Pain 2015;7:367
  2. Role of anoctamin-1 and bestrophin-1 in spinal nerve ligation-induced neuropathic pain in rats.
    Authors: Pineda-Farias Et al.
    Cell Death Dis 2015;11:41
  3. Anoctamin Calcium-Activated Chloride Channels May Modulate Inhibitory Transmission in the Cerebellar Cortex.
    Authors: Zhang Et al.
    PLoS One 2015;10:e0142160
  4. Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina.
    Authors: Jeon Et al.
    PLoS One 2013;8:e67989
  5. Chloride channels are necessary for full platelet phosphatidylserine exposure and procoagulant activity.
    Authors: Harper and Poole
    PLoS One 2013;4:e969

Have you used T16Ainh - A01?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Note:

Contact Information

Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee

Feedback

Customer Information