Induces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α
values are 20, 32 and 32 nM respectively).
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Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling.
Laco et al.