Thalidomide - linker 3
Chemical Name: N-(4-Aminobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Biological ActivityFunctionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a short alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Drug development. Phthalimide conjugation as a strategy for in vivo target protein degradation.
Winter et al.
Waste disposal-An attractive strategy for cancer therapy.
Salami et al.
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