Thalidomide - linker 4

Catalog # Availability Size / Price Qty
6627/25
Cat.No. 6627 - Thalidomide - linker 4 | C19H23N3O5.HCl
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Description: Thalidomide-alkylC6-amine

Chemical Name: 4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride

Purity: ≥95%

Product Details
Reviews

Biological Activity

Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a C6 alkyl linker ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTACs R&D.

Technical Data

M.Wt:
409.86
Formula:
C19H23N3O5.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The dTAG system for immediate and target-specific protein degradation.
    Nabet et al.
    Nat.Chem.Biol., 2018;14:431
  2. Transcription control by the ENL YEATS domain in acute leukaemia.
    Erb et al.
    Nature., 2017;543:270

Product Datasheets

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