Catalog Number: 0919
Chemical Name: 1-(2-Trifluoromethylphenyl)imidazole
Biological Activity
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC50 values of 28.2, 27.0 and 1057.5 μM respectively). Antinociceptive in vivo.
Technical Data
  • M.Wt:
    212.17
  • Formula:
    C10H7F3N2
  • Solubility:
    Soluble to 100 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    25371-96-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nitric oxide mediates activity-dependent plasticity of retinal bipolar cell output via S-nitrosylation.
    Tooker et al.
    J.Neurosci., 2013;33:19176
  2. The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse.
    Handy et al.
    Br.J.Pharmacol., 1995;116:2349
  3. Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl)imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects.
    Handy et al.
    Br.J.Pharmacol., 1996;119:423
Citations:

The citations listed below are publications that use Tocris products. Selected citations for TRIM include:

1 Citations: Showing 1 - 1

  1. Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils.
    Authors: Zanardo Et al.
    Proc Natl Acad Sci U S A 1997;94:14111

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