Catalog Number: 0579
Chemical Name: (S)-(E)-2-Cyano-3-(3',4'-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide
Biological Activity

Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Slightly less active than the (-) enantiomer.

(-)-enantiomer also available.
Technical Data
  • M.Wt:
    308.34
  • Formula:
    C18H16N2O3
  • Solubility:
    Soluble to 30 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
    133550-37-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. Tyrphostins. 2. Heterocyclic and α-substituted benzylidenemalononitrile tyrophostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.
    Gazit et al.
    J.Med.Chem., 1991;34:1896

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