Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Biological ActivityPotent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).
Fray and Dickinson
Citation for UK 356618
The citations listed below are publications that use Tocris products. Selected citations for UK 356618 include:
1 Citation: Showing 1 - 1
Nestin depletion induces melanoma matrix metalloproteinases and invasion.
Authors: Lee Et al.
Lab Invest 2014;94:1382
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