Catalog Number: 4187
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Biological Activity
Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Technical Data
  • M.Wt:
    557.72
  • Formula:
    C34H43N3O4
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    230961-08-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.
Background References
  1. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).
    Fray and Dickinson
    Bioorg.Med.Chem.Lett., 2001;11:571
Citations:

The citations listed below are publications that use Tocris products. Selected citations for UK 356618 include:

1 Citations: Showing 1 - 1

  1. Nestin depletion induces melanoma matrix metalloproteinases and invasion.
    Authors: Lee Et al.
    Lab Invest 2014;94:1382

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