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UK 356618

4187 1 Citation Datasheet / COA / SDS
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4187/10
UK 356618 | CAS No. 230961-08-7 | Synthetic Metalloprotease Inhibitors
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Description: Potent and selective MMP-3 inhibitor

Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine

Purity: ≥95%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

UK 356618 is a potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).

Technical Data

M.Wt:
557.72
Formula:
C34H43N3O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
230961-08-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Background References

  1. Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1).
    Fray and Dickinson
    Bioorg.Med.Chem.Lett., 2001;11:571

Product Datasheets

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Citation for UK 356618

The citations listed below are publications that use Tocris products. Selected citations for UK 356618 include:

1 Citation: Showing 1 - 1

  1. Nestin depletion induces melanoma matrix metalloproteinases and invasion.
    Authors: Lee Et al.
    Lab Invest  2014;94:1382

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