W146

  ( 4 citations )    
Product Datasheet
Catalog Number:3602
Alternate Names:ML 056
Chemical Name:[(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl]-phosphonic acid
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent sphingosine-1-phosphate receptor S1P1 selective antagonist (Ki = 18 nM); displays no effect at S1P2, S1P3 or S1P5. Enhances capillary leakage and restores lymphocyte egress in vivo.
Technical Data
  • M.Wt:
    342.37
  • Formula:
    C16H27N2O4P
  • Solubility:
    Soluble to 20 mM in 3eq. NaOH
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    909725-61-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for W146 include:

4 Citations: Showing 1 - 4
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  1. Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model.
    Authors: Schuhmann Et al.
    Mol Cell Biol  2015;16:29454
  2. Fingolimod induces neuroprotective factors in human astrocytes.
    Authors: Hoffmann Et al.
    J Neuroinflammation  2015;12:184
  3. Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.
    Authors: Beckham Et al.
    PLoS One  2013;8:e76593
  4. Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling.
    Authors: Beckham Et al.
    Oncogenesis  2013;2:e49

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