W146

Key Product Details

Product Description

W146 is a potent sphingosine-1-phosphate receptor S1P₁ selective antagonist (K_i = 18 nM); displays no effect at S1P₂, S1P₃ or S1P₅. Enhances capillary leakage and restores lymphocyte egress in vivo.

Product Specifications for W146

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for W146

The following data is based on the product molecular weight 342.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.60 mL	73.02 mL	146.04 mL
1 mM	2.92 mL	14.60 mL	29.21 mL
2 mM	1.46 mL	7.30 mL	14.60 mL
10 mM	0.29 mL	1.46 mL	2.92 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 28 publications citing the usage of this product.

• Gonzalez-Cabrera Full pharmacological efficacy of a novel S1P₁ agonist that does not require S1P-like headgroup interactions. Mol.Pharmacol. 2008 PMID: 18708635
• Sanna Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P₁ antagonist in vivo. Nat.Chem.Biol. 2006 PMID: 16829954

Product Documents for W146