Catalog Number: 1057
Chemical Name: (S)-4-[2-[Bis(cyclohexylamino)methyleneamino]-3-(2-naphthalenyl)-1-oxopropylamino]benzyl tributyl phosphonium chloride hydrochloride
Biological Activity
The first potent, non-peptide, competitive bradykinin B2 receptor antagonist. In organ bath studies, WIN 64338 inhibits [3H]-bradykinin binding on guinea pig trachea with nanomolar affinity but is not active in the rabbit aorta (the classical bradykinin B1 preparation).
Technical Data
  • M.Wt:
    783.95
  • Formula:
    C45H68ClN4OP.HCl
  • Solubility:
    Soluble to 75 mM in DMSO
  • Storage:
    Desiccate at +4°C
  • CAS No:
    163727-74-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Action of bradykinin in the submucosal plexus of guinea pig small intestine.
    Hu et al.
    J.Pharmacol.Exp.Ther., 2004;309:320
  2. Effects of peptide and nonpeptide antagonists of bradykinin B2 receptors on the venoconstrictor action of bradykinin.
    Marceau et al.
    J.Pharmacol.Exp.Ther., 1994;269:1136
  3. Effects of WIN 64338, a nonpeptide bradykinin B2 receptor antagonist, on guinea-pig trachea.
    Scherrer et al.
    Br.J.Pharmacol., 1995;115:1127
Citations:

The citations listed below are publications that use Tocris products. Selected citations for WIN 64338 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Factors mediating remote preconditioning of trauma in the rat heart: central role of the cytochrome p450 epoxygenase pathway in mediating infarct size reduction.
    Authors: Gross Et al.
    J Cardiovasc Pharmacol Ther 2013;18:38

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