Catalog Number: 3413
Chemical Name: N-Cyclohexyl-6-[[N-(2-methoxyethyl)-N-methylamino]methyl]-N-methylthiazolo[3,2-a]benzoimidazole-2-carboxamide sesquifumarate
Biological Activity
High affinity, selective metabotropic glutamate receptor type 1 (mGlu1) antagonist. Binds an allosteric site of the rat mGlu1 receptor with a Ki of 4.8 nM. Inhibits mGlu1-mediated inositol phosphates production (IC50 = 8.6 nM in rat cerebellar granule cells). Neuroprotective in vivo.
Technical Data
  • M.Wt:
    588.67
  • Formula:
    C22H30N4O2S.1.5C4H4O4
  • Solubility:
    Soluble to 20 mM in water and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    299900-84-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models.
    Kohara et al.
    Brain Res., 2008;1191:168
  2. Metabotropic glutamate 1 receptor: current concepts and perspectives.
    Ferraguti et al.
    Pharmacol.Rev., 2008;60:536
  3. Radiosynthesis and evaluation of [11C]YM-202074 as a PET ligand for imaging the metabotropic glutamate receptor type 1.
    Yanamoto et al.
    Nucl.Med.Biol., 2010;37:615

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