Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
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Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes Dym loss, caspase-9 activity, and apoptosis in Jurkat cells.
Gamen et al.
Exp.Cell Res., 2000;258:223
Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.
Meguro et al.
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.
Robertson et al.