Catalog Number: 2165
Chemical Name: Benzyloxycarbonyl-Val-Asp(OMe)-Val-Ala-Asp(OMe)-fluoromethylketone
Biological Activity
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Technical Data
  • M.Wt:
    695.74
  • Formula:
    C32H46FN5O11
  • Sequence:
    VDVAD

    (Modifications: Val-1 = Z-Val, Aps-2 = Asp(OMe), Asp-5 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.91 mg/ml in DMSO
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes Dym loss, caspase-9 activity, and apoptosis in Jurkat cells.
    Gamen et al.
    Exp.Cell Res., 2000;258:223
  2. Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells.
    Meguro et al.
    Stroke, 2001;32:561
  3. Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis.
    Robertson et al.
    J.Biol.Chem., 2002;277:29803

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    2165 has been discontinued.

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