Catalog Number: 0930
Alternate Names: ICI D7114
Chemical Name: (S)-4-[2-Hydroxy-3-phenoxypropylaminoethoxy]-N-(2-methoxyethyl)phenoxyacetamide hydrochloride
Biological Activity
β3-adrenoceptor agonist.

Active Metabolite also available.

Technical Data
  • M.Wt:
    454.95
  • Formula:
    C22H30N2O6.HCl
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    129689-28-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of AstraZeneca UK Ltd.
Other Product-Specific Information:
Background References
  1. Evaluation of ICI D7114, a putative stimulant of brown adipocytes, on histamine-contracted guinea-pig ileum.
    Growcott et al.
    Br.J.Pharmacol., 1993;109:1212
  2. Effects of ZD7114, a selective β3-adrenoceptor agonist, on neuroendocrine mechanisms controlling energy balance.
    Savontaus et al.
    Eur.J.Pharmacol., 1998;347:265
  3. β3-Adrenergic agonists.
    How
    Drugs Future, 1993;18:529
Citations:

The citations listed below are publications that use Tocris products. Selected citations for ZD 7114 hydrochloride include:

2 Citations: Showing 1 - 2
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  1. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
    Authors: Suárez Et al.
    Dis Model Mech 2014;7:129
  2. Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses.
    Authors: Baker Et al.
    FASEB J 2011;25:4486

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