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Adenosine A1 Receptors

Adenosine A1 Receptor (ADORA1) is an adenosine receptor that belongs to the G protein-coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The ADORA1 receptor inhibits adenylyl cyclase, and plays a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication.