Adenosine A2A Receptors

Adenosine A2A Receptor (ADORA2A) is one of several receptor subtypes for adenosine. The activity of ADORA2A, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. ADORA2A is abundant in basal ganglia, vasculature and platelets and is a major target of caffeine. Variability in the acute blood pressure response to coffee may be partly explained by genetic polymorphisms of the adenosine A2A receptors, including ADORA2A, and alpha(2)-adrenergic receptors.