Common beta Chain Family Receptors

The receptors for human granulocyte macrophage-colony stimulating factor (GM-CSF), IL-3 and IL-5 are comprised of a cytokine-specific alpha chain, and a common beta chain. The common beta chain on GM-CSF, IL-3, and IL-5 receptors interacts with all three ligands, promoting some degree of overlap between their regulation of hematopoietic cell signaling.