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Flamingo Subfamily

CELSR2 (Cadherin EGF LAG seven-pass G-type receptor 2; also cadherin family member 10/CDHF10, Flamingo1 and EGFL2) and CELSR3 are members of the LN-7TM subfamily, GPCR 2 family of proteins. Also known as the flamingo subfamily, these non-classic cadherins do not interact with catenins. Located at the plasma membrane, CELSR2 and CELSR3 are structurally characterized by seven transmembrane domains, with nine cadherin domains, seven epidermal growth factor-like repeats, and two laminin A G-type repeats in the extracellular domain. CELSR2 is expressed on neurons, breast epithelium, Sertoli cells and germ cells, and through homophilic interactions, serves as either an adhesion or guidance molecule. Both CELSR2 and CELSR3 are known to be critical factors in the development and function of ependymal cilia, and the circulation of the cerebrospinal fluid (CSF) in the brain. Recent studies also suggest that CELSR3 may have an important role during development of GABA circuits in the inner retina.