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FLRT1, 2, and 3 are type I transmembrane glycoproteins that are characterized by the presence of ten leucine-rich repeats and a juxtamembrane fibronectin type-III domain. FLRT proteins differ in their tissue distribution in the embryo and adult. They modulate FGF R signaling and homotypic cell adhesion. FLRT3 also promotes neurite outgrowth.