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METAP (Methionine Aminopeptidase)

METAPs play a central role for protein maturation as they remove the initiator Met residue from newly synthesized proteins. Three METAP genes (METAP1, METAP2 and MAP1D) have been identified in the human genome. Fumagillin, a natural compound, covalently modifies an active His residue of METAP2 and prevents the vascularization and metasis of tumors.