Prostaglandin J2/PGJ2

15-deoxy-D12,14-Prostaglandin J2 (15-d-PGJ2) is one of the ultimate dehydration products of PGD2. PGD2 is formed from PGH2 which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthase. 15-d-PGJ2 induces adipogenesis and is an activator of the gamma isoform of the peroxisome proliferation activated receptor (PPARg).