SorCS Family

SorCS proteins are members of the Vps10p (vacuolar protein-sorting 10 protein) family of sorting receptors. They are synthesized as proforms that undergo proteolytic processing to generate mature type I transmembrane receptors. The extracellular domains (ECD) show an imperfect LRR plus a Vps10p domain. The SorCS1 Vps10p domain binds both PDGF-BB and NGF-propeptide, while the SorCS3 Vps10p domain binds both pro- and mature NGF.