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Stabilin Family

Stabilin-1 and -2 are type I transmembrane members of a family of fasciclin-like Hyaluronan (HA) receptor homologs. Both contain fasciclin-like adhesion domains, EGF-like repeats, and hyaluronan-binding motifs, and both are expressed on sinusoidal endothelium and macrophages. Functionally, they are distinct. Stabilin-1 acts to clear unwanted self-molecules, while Stabilin-2 acts as a scavenger receptor for HA and AGE-modified proteins.