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UbcH5 enzymes are human homologs of the yeast UBC4/5 family and play many importantregulatory roles in inflammation and cancer. UbcH5a mediates the degradation of a myriad of short-lived regulatory proteins (such as p53 in the presence of E6/E6-AP or MDM2, c-Fos, IkBa, p105) and abnormal proteins. Ubch5a has 89% and 88% sequence identity with Ubch5b and Ubch5c respectively.