Citations: Recombinant Mouse Wnt-3a and Wnt-5a

Members of the Wnt Family are extracellular glycoproteins that regulate multiple early developmental processes including tissue morphogenesis, cell differentiation, and axon guidance. Our active mouse Wnt-3a and Wnt-5a have been utilized as important tools in several recent studies assessing the role of Wnts in multiple aspects of embryonic development and in tumor formation.

Mouse Wnt-3a

(Catalog # 1324-WN-002)

  • 4 Watanabe, K. et al. (2005) Directed differentiation of telencephalic precursors from embryonic stem cells. Nature Neuroscience 8:288.
    Sample Type: Mouse embryonic stem cells
  • 4 Kennell, J.A. & O.A. MacDougal (2005) Wnt signaling inhibits adipogenesis through β-catenin-dependent and -independent mechanisms. Journal of Biological Chemistry 280:24004.
    Sample Type: Mouse pre-adipocytes (3T3-L1)
  • 4 Kimura-Yoshida, C. et al. (2005) Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Developmental Cell 9:639.
    Sample Type: Mouse embryo in vivo
  • 4 Clement-Lacroix, P. et al. (2005) LRP5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proceedings of the National Academy of Science USA 102:17406.
    Sample Type: Mouse calvarial osteoblasts
  • 4 Lowry, W.E. et al. (2005) Defining the impact of β-catenin/TCF transactivation on epithelial stem cells. Genes & Development 102:17406.
    Sample Type: Mouse keratinocytes and follicular bulge stem cells
  • 4 Dravid, G. et al. (2005) Defining the role of Wnt/β-catenin signaling in the survival, proliferation, and self renewal of human embryonic stem cells. Stem Cells 23:1489.
    Sample Type: Human embryonic stem cells (H1 & H9)
  • 4 Murashov, A.K. et al. (2005) Directed differentiation of embryonic stem cells into dorsal interneurons. FASEB Journal 19:252.
    Sample Type: Mouse embryonic stem cells (WW6)

Mouse Wnt-5a

(Catalog # 645-WN-010)

  • 4 Kremenevskaja, N. et al. (2005) Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 24:2144.
    Sample Type: Human thyroid cells (FTC-133)
  • 4 Schulte, G. et al. (2005) Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation. Journal of Neurochemistry 92:1550.
    Sample Type: Mouse embryonic dopaminergic cells (SN4741)