TACE (tumor necrosis factor-alpha converting enzyme) is a transmembrane ADAM (a disintegrin and metalloproteinase-like) family member present within most tissues. It cleaves the membrane-bound TNF-alpha precursor to generate the secreted, mature protein. TACE is also involved in the extracellular domain cleavage of a variety of proteins, such as APP, L-selectin, TGF-alpha, and Notch1 receptor. TACE is an alpha-secretase, which cleaves APP within the amyloid sequence, preventing the formation of alpha/beta and creating non-amyloidogenic products.
BACE-1 [beta-site amyloid precursor protein (APP) cleaving enzyme] is a transmembrane aspartic protease found within the Golgi apparatus, trans-Golgi network, secretory vesicles, and endosomes. BACE-1 exhibits all the properties expected for beta-secretase. beta-secretase is predominantly responsible for cleavage of APP in the brain to generate amyloid beta peptide (Ab), a major component of the amyloid plaques associated with Alzheimer's Disease (AD). As such, BACE-1 has been implicated in the onset and/or progression of AD.
Inhibition of BACE or the stimulation of TACE may represent potential therapeutic interventions in AD.
Affinity-purified Polyclonal Antibodies
Please note the following errors in the printed version of this article.
TACE: The source should be T. ni (not NS0), and the specific activity is measured with 10 µM peptide substrate (not 10 mM).