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LIF: Products

LIF (Leukemia Inhibitory Factor) is a pleiotropic member of the IL-6 family of cytokines. It functions through a heterodimeric receptor complex containing a ligand-binding subunit, LIF R alpha/CD118, and a signal transducing subunit, gp130. gp130 also serves as a subunit of the receptor complexes for Oncostatin M, Cardiotrophin-1, CNTF, IL-6, IL-11, and IL-27. LIF supports uterine implantation of the embryo, pluripotency in embryonic stem cells, and proliferation of progenitor cells. It promotes regulatory T cell and inhibits Th17 cell differentiation, and it is required by the thymic epithelium to support T cell maturation. It promotes motor neuron survival and oligodendrocyte myelination, enhances adrenal production of cortisol and aldosterone, and promotes differentiation of adipocytes and cardiac smooth muscle cells. LIF can also function as an autocrine growth factor in pancreatic cancer and can induce formation of immunosuppressive tumor-associated macrophages.

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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B11  
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Proteome Profiler Mouse XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
ARY0283  
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Proteome Profiler Mouse Angiogenesis Array Kit


Contains 4 membranes - each spotted in duplicate with 53 different angiogenesis antibodies
ARY01531  
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Proteome Profiler Mouse Adipokine Array Kit


Contains 4 membranes - each spotted in duplicate with 38 different obesity-related antibodies
ARY0137  
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Proteome Profiler Human Adipokine Array Kit


Contains 4 membranes-each spotted in duplicate with 58 different obesity-related antibodies
ARY0241  
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Proteome Profiler Rat Adipokine Array Kit


Contains 4 membranes - each spotted in duplicate with 30 different obesity-related antibodies
ARY016 
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Proteome Profiler Rat XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
ARY030 
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