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Osteopontin/OPN: Products

Osteopontin (OPN), also known as bone sialoprotein (BSP), is a secreted SIBLING family protein that can be variably modified by O- and N-glycosylation, sulfation, phosphorylation, and transglutamination. OPN is widely expressed and is prominent in mineralized tissues. It inhibits bone mineralization and kidney stone formation and promotes inflammation, cell ad­hesion, and migration. Its expression is upregulat­ed during inflammation, obesity, atherosclerosis, cancer, and tissue damage and contributes to the pathophysiology of these conditions. The central region of OPN contains RGD and non-RGD binding sites for multiple integrins. Adjacent to the RGD motif is the sequence SLAYGLR (SVVYGLR in human) which serves as a cryptic binding site for additional integrins: it is masked in full length OPN but is exposed following OPN cleavage by multiple proteases in tumors and sites of tissue injury.

Showing 1-6 out of 6 Osteopontin/OPN Products

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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B16  
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Proteome Profiler Mouse XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 111 different cytokine antibodies
ARY02811  
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Proteome Profiler Human sReceptor Array, Non-hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY01210  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY0262  
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Proteome Profiler Rat XL Cytokine Array


Contains 4 membranes-each spotted in duplicate with 79 different cytokine antibodies
ARY030 
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Proteome Profiler Human sReceptor Array, Hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 48 different hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0111  
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