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Thrombospondin-1: Products

Thrombospondin-1 (TSP-1) is a secreted homotrimeric protein that regulates a wide range of cellular functions including their interactions with other cells and with the extracellular matrix (ECM). TSP-1 counteracts the angiogenic, hypotensive, and anti-thrombotic effects of nitric oxide (NO). It binds and neutralizes VEGF, blocks VEGF R2 signaling on vascular endothelial cells (EC), and destabilizes adhesive contacts between EC. TSP-1 also plays an important role in wound repair and tissue fibrosis by binding latent TGF-beta and inducing release of the active cytokine from the latency associated peptide (LAP). TSP-1 dampens adaptive immune responses by inducing the differentiation of regulatory T cells and inhibiting TCR signaling. In the nervous system, it promotes excitatory synapse formation and supports the integration of neural progenitor cells into the olfactory bulb.

Showing 1-6 out of 6 Thrombospondin-1 Products

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Proteome Profiler Human Angiogenesis Array Kit


Contains 4 membranes - each spotted in duplicate with 55 different angiogenesis antibodies
ARY00766  
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Proteome Profiler Human XL Cytokine Array Kit


Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
ARY022B11  
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Proteome Profiler Human sReceptor Array, Non-hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 62 different non-hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY01210  
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Proteome Profiler Human XL Oncology Array


Contains 4 membranes-each spotted in duplicate with 84 different cancer-related antibodies
ARY0261  
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Proteome Profiler Human sReceptor Array, Hematopoietic


Contains 4 membranes - 2 spotted in duplicate with 48 different hematopoietic antibodies and 2 spotted in duplicate with 57 common antibodies
ARY0111  
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Proteome Profiler Human Kidney Biomarker Array Kit


Contains 4 membranes - each spotted in duplicate with 38 different kidney biomarker antibodies
ARY0191  
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