20S Proteasome: Products

The 20S Proteasome is the catalytic core component of the multi-complex 26S Proteasome that selectively degrades intracellular proteins. It is commonly associated with regulatory complexes, which include the 19S Proteasome, the PA28 alpha/beta complex, or the PA28 gamma complex. The 20S Proteasome is composed of 28 subunits arranged into four stacked rings. The outer rings, containing seven subunits each, are composed of closely-related but non-identical alpha subunits. The amino-terminal tails of the alpha subunits form a gate that restricts substrate entry into the catalytic core. The inner rings, also containing seven subunits each, are composed of closely-related but non-identical beta subunits. The amino-terminal tails of six of the beta subunits, three per ring, have proteolytic activity. Inhibition of 20S Proteasome proteolytic core activity using small molecule inhibitors is a valuable tool for the functional study of a variety of proteins and for therapeutic intervention. The 20S Proteasome can be activated chemically by the addition of detergent or by the proteinaceous activator PA28 Activator alpha.

Showing 1-9 out of 9 20S Proteasome Products

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Human 20S Proteasome Protein, CF

 E-3609  
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Rabbit 20S Proteasome Protein, CF

 E-350 
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20S Proteasome Assay Kit (SDS Activation Format)

K-900 
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AM 114


20S proteasome inhibitor
2564 
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100X 20S Proteasome Activation Solution

B-30 
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Canine 20S Proteasome Protein, CF

 E-358 
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Mouse 20S Proteasome Protein, CF

 E-355 
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Rat 20S Proteasome Protein, CF

 E-352 
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20X 20S Proteasome Reaction Buffer

B-80 
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