5-HT4: Products

5HT4R, also known as HTR4, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5HT4R generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5HT4R shares 94% and 88% aa sequence identity with mouse and rat 5HT4R, respectively.

Showing 1-19 out of 19 5-HT4 Products

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GR 125487 sulfamate


Potent, selective 5-HT4 antagonist; active in vivo
16582  
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RS 67333 hydrochloride


5-HT4 partial agonist
09895  
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Zacopride hydrochloride


Highly potent 5-HT3 receptor antagonist. Also 5-HT4 agonist
17952  
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Cisapride


5-HT4 agonist; stimulates intestinal ACh release
16951  
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Human 5-HT4 Antibody

IHCMAB6545 
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RS 23597-190 hydrochloride


5-HT4 antagonist
07283  
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2-[1-(4-Piperonyl)piperazinyl]benzothiazole


5-HT4 agonist. Also 5-HT3 antagonist
07361  
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RS 39604 hydrochloride


5-HT4 antagonist
09913  
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GR 113808


Potent, selective 5-HT4 antagonist
13223  
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SB 203186 hydrochloride


5-HT4 antagonist
0785 
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RS 67506 hydrochloride


5-HT4 partial agonist
09901  
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Mosapride citrate


5-HT4 agonist and 5-HT3 antagonist
2844 
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SDZ 205-557 hydrochloride


5-HT4/5-HT3 receptor antagonist
2037 
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ML 10302 hydrochloride


Potent and selective 5-HT4 partial agonist
3499 
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Tegaserod maleate


5-HT4 partial agonist
4613 
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CJ 033466


Selective 5-HT4 partial agonist
3089 
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SB 204070


Potent and selective 5-HT4 antagonist
1373 
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BIMU 8


Potent 5-HT4 receptor full agonist
43741  
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Human 5-HT4 (NP_000861) VersaClone cDNA

RDC0248 
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