5-HT4 Receptor Antagonists: Products

5HT4R, also known as HTR4, is an approximately 45 kDa multipass serotonin receptor that is expressed in the brain, gastrointestinal tract, bladder, vascular endothelial cells, atrium, kidney, and adrenal gland. It is involved in the regulation of learning, memory, anxiety, smooth muscle contraction, and adrenal corticosteroid secretion. Alternate splicing of human 5HT4R generates multiple isoforms with either a 14 aa insertion in the second extracellular loop or a deletion or various substitutions in the C-terminal cytoplasmic region. Different isoforms show tissue specific expression patterns or increased activity in the absence of ligand. Human 5HT4R shares 94% and 88% aa sequence identity with mouse and rat 5HT4R, respectively.

Showing 1-7 out of 7 5-HT4 Receptor Antagonists Products

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GR 113808


Potent, selective 5-HT4 antagonist
13223  
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GR 125487 sulfamate


Potent, selective 5-HT4 antagonist; active in vivo
16582  
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SB 203186 hydrochloride


5-HT4 antagonist
0785 
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RS 23597-190 hydrochloride


5-HT4 antagonist
07283  
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RS 39604 hydrochloride


5-HT4 antagonist
09913  
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SDZ 205-557 hydrochloride


5-HT4/5-HT3 receptor antagonist
2037 
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SB 204070


Potent and selective 5-HT4 antagonist
1373 
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