AGTR-1: Products

The Angiotensin II Receptor, Type 1 (AGTR-1), also known as AT1, is a member of a family of seven transmembrane G protein-coupled receptors that mediates the effects of Angiotensin II, the major bioactive peptide of the renin-angiotensin system. AGTR-1 is 359 amino acids (aa) in length with a predicted molecular weight of 41.1 kDa. Human AGTR-1 shares 94% and 95% aa sequence identity with mouse and rat orthologs, respectively. Interestingly, most species express a single AGTR-1 gene while rodents contain two related genes, which are termed AGTR-1A and AGTR-1B. AGTR-1 is widely expressed with the highest levels being found in the liver, kidney, adrenal glands, brain, heart, vasculature, and lungs. It is coupled to G proteins containing the alphaq/11 subunits and has been shown to activate the PLC-IP3-Ca2+ and PLC-DAG-PKC, MAPK, and Jak/STAT signal transduction pathways. AGTR-1 has been shown to mediate most of the physiological actions of Angiotensin II including vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration, and sympathetic stimulation. Additionally, AGTR-1 has been suggested to play a role in the induction of reperfusion arrhythmias. AGTR-1 antagonists are used to treat hypertension, diabetic nephropathy, and congestive heart failure.

Showing 1-18 out of 18 AGTR-1 Products

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Losartan potassium


Selective, non-peptide AT1 antagonist
37985  
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Angiotensin II


Potent vasoconstrictor peptide
11585  
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Olmesartan


Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)
4616 
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ZD 7155 hydrochloride


Selective non-peptide AT1 antagonist
12112  
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Telmisartan


AT1 antagonist; PPARgamma partial agonist
51391  
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Candesartan


AT1 receptor antagonist
4791 
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Eprosartan mesylate


Potent and selective AT1 receptor antagonist
4696 
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EMD 66684


Potent, selective non-peptide AT1 antagonist
1849 
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Candesartan cilexetil


Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist
4792 
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Azilsartan


Potent AT1 receptor inverse agonist; antihypertensive
4553 
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Valsartan


High affinity, selective AT1 antagonist
4216 
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Irbesartan


Potent AT1 antagonist
5798 
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EXP 3174


Potent and selective AT1 receptor antagonist
5728 
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Olmesartan medoxomil


Selective non-peptide AT1 antagonist; prodrug of Olmesartan
4620 
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Saralasin


Non-selective angiotensin II antagonist
1163 
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Human AGTR-1 (NP_000676) VersaClone cDNA

RDC0098 
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Mouse AGTR-1B (NP_780295) VersaClone cDNA

RDC0573 
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Mouse AGTR-1A (NP_796296) VersaClone cDNA

RDC0572 
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