AGTR-1: Products

The Angiotensin II Receptor, Type 1 (AGTR-1), also known as AT1, is a member of a family of seven transmembrane G protein-coupled receptors that mediates the effects of Angiotensin II, the major bioactive peptide of the renin-angiotensin system. AGTR-1 is 359 amino acids (aa) in length with a predicted molecular weight of 41.1 kDa. Human AGTR-1 shares 94% and 95% aa sequence identity with mouse and rat orthologs, respectively. Interestingly, most species express a single AGTR-1 gene while rodents contain two related genes, which are termed AGTR-1A and AGTR-1B. AGTR-1 is widely expressed with the highest levels being found in the liver, kidney, adrenal glands, brain, heart, vasculature, and lungs. It is coupled to G proteins containing the alphaq/11 subunits and has been shown to activate the PLC-IP3-Ca2+ and PLC-DAG-PKC, MAPK, and Jak/STAT signal transduction pathways. AGTR-1 has been shown to mediate most of the physiological actions of Angiotensin II including vasoconstriction, aldosterone and vasopressin release, salt and water retention, cell proliferation and migration, and sympathetic stimulation. Additionally, AGTR-1 has been suggested to play a role in the induction of reperfusion arrhythmias. AGTR-1 antagonists are used to treat hypertension, diabetic nephropathy, and congestive heart failure.

Showing 1-17 out of 17 AGTR-1 Products

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Angiotensin II


Potent vasoconstrictor peptide
11587
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Losartan potassium


Selective, non-peptide AT1 antagonist
37986
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Candesartan


AT1 receptor antagonist
4791
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Saralasin


Non-selective angiotensin II antagonist
11631
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ZD 7155 hydrochloride


Selective non-peptide AT1 antagonist
12112
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EMD 66684


Potent, selective non-peptide AT1 antagonist
1849
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Valsartan


High affinity, selective AT1 antagonist
4216
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Azilsartan


Potent AT1 receptor inverse agonist; antihypertensive
4553
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Olmesartan


Potent AT1 antagonist; metabolite of Olmesartan medoxomil (Cat. No. 4620)
4616
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Candesartan cilexetil


Prodrug of candesartan (Cat. No. 4791), an AT1 receptor antagonist
4792
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Telmisartan


AT1 antagonist; PPARγ partial agonist
51391
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EXP 3174


Potent and selective AT1 receptor antagonist
5728
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Irbesartan


Potent AT1 antagonist
5798
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Human AGTR-1 (NP_000676) VersaClone cDNA

RDC0098 
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Mouse AGTR-1A (NP_796296) VersaClone cDNA

RDC0572 
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Mouse AGTR-1B (NP_780295) VersaClone cDNA

RDC0573 
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Rat AGTR-1 (NP_112247) VersaClone cDNA

RDC2390 
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