AHR: Products

AHR (Aryl-hydrocarbon receptor; also bHLHE76) is a 110 kDa member of the bHLH/PAS transcription factor family. It is widely expressed (breast, lung, liver), and serves many functions. First, it binds multiple xenobiotic chemicals in the cytoplasm. This induces dimerization with ARNT, translocation to the nucleus, and activation of P450 genes such as CYP1A1 and UGT1A6. Second, it appears to block cell cycle progression, possibly via a down-regulation of CDK proteins. And third, it blocks apoptosis by interacting with E2F1, thus silencing TP73 and Apaf1 genes. Human AHR is 848 amino acids (aa) in length. It contains a 10 aa prosegment, plus a 838 aa mature molecule that contains a DNA binding motif (aa 13-40), a bHLH region (aa 41-81), and two PAS domains (aa 111-342). Over aa 704-848, human AHR shares 70% aa identity with mouse AHR.

Showing 1-14 out of 14 AHR Products

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Human AHR Antibody


Recombinant Monoclonal Antibody.
ICC/IF, WBMAB61851 
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ITE


Endogenous agonist for the transcription factor aryl hydrocarbon receptor
18034  
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FICZ


High affinity aryl hydrocarbon receptor (AhR) agonist
5304 
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Human AHR Antibody

Flow, ICC/IF, SW, WBAF6185 
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Human/Mouse AHR Antibody

ICC/IF, WBAF6697 
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CH 223191


Potent aryl hydrocarbon receptor (AhR) antagonist
38583  
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L-Kynurenine


Tryptophan catabolite; endogenous aryl hydrocarbon receptor ligand
4393 
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Human AHR Antibody

IHCMAB6185 
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MeBIO


Inactive analog of BIO (Cat. No. 3194)
3873 
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Mouse AHR APC-conjugated Antibody

FlowIC6697A 
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Mouse AHR Alexa Fluor® 488-conjugated Antibody

FlowIC6697G 
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Mouse AHR PE-conjugated Antibody

FlowIC6697P 
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6,2',4'-Trimethoxyflavone


Aryl hydrocarbon receptor antagonist
3859 
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DiMNF


Selective aryl hydrocarbon receptor modulator (SAhRM)
4628 
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