ALK Inhibitors: Products

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

Showing 1-6 out of 6 ALK Inhibitors Products

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KRCA 0008


Potent Ack1 and ALK dual inhibitor; orally bioavailable
5098 
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GSK 1838705


Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)
5111 
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ASP 3026


Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
5310 
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PF 06463922


High affinity and selective ALK and ROS1 inhibitor
5640 
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LDN 212854


Potent bone morphogenetic protein type I (ALK) inhibitor
6151 
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Crizotinib


Potent c-MET/ALK inhibitor
43683  
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