ALK/CD246: Products

Anaplastic Lymphoma Kinase (ALK), also known as CD246, is a 220 kDa transmembrane glycoprotein that is primarily expressed in the developing nervous system. ALK contains one LDL Receptor (LDLR) class A domain, two meprin/A5-protein/PTPmu (MAM) domains, and a cytoplasmic kinase domain. Chromosomal translocation involving ALK and the nucleolar NPM protein result in a cytoplasmic fusion protein that exists as a dimer. The kinase domain in NPM-ALK is constitutively active and participates in cellular transformation. ALK translocations are found in a variety of tumors. Within the extracellular domain, human and mouse ALK share 88% amino acid sequence identity.

Showing 1-7 out of 7 ALK/CD246 Products

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Proteome Profiler Human Phospho-RTK Array Kit


Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
ARY001B96  
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Human ALK/CD246 Antibody

IHC, WBAF4210 
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Human ALK/CD246 Antibody

WBMAB4210 
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KRCA 0008


Potent Ack1 and ALK dual inhibitor; orally bioavailable
5098 
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PF 06463922


High affinity and selective ALK and ROS1 inhibitor
5640 
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ASP 3026


Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
5310 
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Human ALK/CD246 (NP_004295) VersaClone cDNA

RDC1376 
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