AMPK Activators: Products

AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic a subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms (alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations capable of forming complexes. The catalytic a subunit of AMPK is activated allosterically by AMP and by phosphorylation via the AMPK kinase LKB1. Active AMPK downregulates anabolic pathways such as fatty acid, triglyceride, and cholesterol synthesis, and up-regulates catabolic pathways such as glycolysis and fatty acid oxidation. AMPK's role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity, and diabetes.

Showing 1-8 out of 8 AMPK Activators Products

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Metformin hydrochloride


Activator of LKB1/AMPK; antidiabetic agent
28649
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AICAR


AMPK activator
284014
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A 769662


Potent AMPK activator
333618
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PF 06409577


Potent and selective allosteric activator of AMPK
6114
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Cryptotanshinone


STAT3 inhibitor. Also displays multiple other activities
3713
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RSVA 405


AMPK activator; also STAT3 inhibitor
51381
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ZLN 024 hydrochloride


Allosteric AMPK activator
5285
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PT 1


AMPK activator
40391
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